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2374139-68-9

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2374139-68-9 Structure

2374139-68-9 Structure
IdentificationBack Directory
[Name]

[1,1'-Biphenyl]-3-carboxamide, 3'-[[3-(2-fluorophenyl)-5,6-dihydro-5-methylpyrrolo[3,4-c]pyrazol-2(4H)-yl]methyl]-
[CAS]

2374139-68-9
[Synonyms]

P-CAB agent 1
[1,1'-Biphenyl]-3-carboxamide, 3'-[[3-(2-fluorophenyl)-5,6-dihydro-5-methylpyrrolo[3,4-c]pyrazol-2(4H)-yl]methyl]-
[Molecular Formula]

C26H23FN4O
[MOL File]

2374139-68-9.mol
[Molecular Weight]

426.49
Chemical PropertiesBack Directory
[Boiling point ]

632.1±55.0 °C(Predicted)
[density ]

1.29±0.1 g/cm3(Predicted)
[pka]

15.88±0.50(Predicted)
Hazard InformationBack Directory
[Uses]

P-CAB agent 1 (compound B19) is a highly potent potassium-competitive acid blocker agent with an IC50 value of 60.50 nM for H+/K+-ATPase. P-CAB agent 1 has acceptable oral absorption in rats. P-CAB agent 1 can be used for researching acid-related disorders (ARDs)[1].
[in vivo]

P-CAB agent 1 has acceptable oral absorption in rats[1].
Pharmacokinetic Parameters of P-CAB agent 1 in female Sprague-Dawley rats[1].

IV (2 mg/kg)PO (8 mg/kg)
AUC0-∞ (ug/L*hr)519.57341.49
t1/2 (ng/mL)0.490.8
Cmax (ug/L)149.9317
F (%)16.43
[References]

[1] Wang X, et al. Design, synthesis and biological evaluation of novel 5-methyl-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole derivatives as potent potassium-competitive acid blockers. Bioorg Med Chem. 2022 Jun 15;64:116765. DOI:10.1016/j.bmc.2022.116765
2374139-68-9 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
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Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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