| Identification | Back Directory | [Name]
1-Piperidinepropanoic acid, (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl ester, hydrochloride (1:1) | [CAS]
2374723-26-7 | [Synonyms]
As-358 hydrochloride
1-Piperidinepropanoic acid, (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl ester, hydrochloride (1:1) | [Molecular Formula]
C18H32ClNO2 | [MOL File]
2374723-26-7.mol | [Molecular Weight]
329.91 |
| Hazard Information | Back Directory | [Uses]
As-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC50s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety[1]. | [in vivo]
As-358 (hydrochloride) (0.14-1.08 g/kg; IG; single) exhibits no toxicity to adult mice with intragastric administration[1]. | Animal Model: | ICR mice[1] | | Dosage: | 1.08, 0.44, 0.27, and 0.14 g/kg | | Administration: | IG; single (observed for 7 days) | | Result: | Exhibited no toxicity to adult mice with intragastric administration, and the LD50 > 1000 mg/kg. |
| [IC 50]
EBOV; MARV | [References]
[1] Sokolova AS, Yarovaya OI, Zybkina AV, et al. Monoterpenoid-based inhibitors of filoviruses targeting the glycoprotein-mediated entry process. Eur J Med Chem. 2020;207:112726. DOI:10.1016/j.ejmech.2020.112726 |
|
|