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Efruxifermin is an Fc-FGF21 fusion protein (human IgG1 Fc domain linked to a modified human FGF21). Efruxifermin has prolonged half-life and enhanced receptor affinity compared with native human FGF21. Efruxifermin can be used for the research of non-alcoholic steatohepatitis[1]. | [in vivo]
Efruxifermin (0-100 mg/kg, SC, Once weekly, for 4 or 26 weeks) reduces body weight gain of Sprague Dawley rats in a dose-dependent manner[1]. | Animal Model: | Male and female Sprague Dawley rats[1] | | Dosage: | 0, 1, 10, 30, 100 mg/kg | | Administration: | Subcutaneous injection, Once weekly, for 4 or 26?weeks | | Result: | Significantly reduced body weight gain after 4 and 26?weeks, despite increasing food intake. Markers of sympathetic activation, urinary corticosterone and ratio of adrenal-to-body weight were unchanged. |
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FGF21 | [References]
[1] Tillman EJ, et al. Efruxifermin, a long-acting Fc-fusion FGF21 analogue, reduces body weight gain but does not increase sympathetic tone or urine volume in Sprague Dawley rats. Br J Pharmacol. 2022 Apr;179(7):1384-1394. DOI:10.1111/bph.15725 |
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