| Identification | Back Directory | [Name]
Benzoic acid, 3-[2-[(2-fluorophenyl)amino]-5-oxazolyl]- | [CAS]
2375281-44-8 | [Synonyms]
NF-κΒ activator 2
3-(2-((2-Fluorophenyl)amino)oxazol-5-yl)benzoic acid
Benzoic acid, 3-[2-[(2-fluorophenyl)amino]-5-oxazolyl]-
Nuclear factor-kappaB,NF-κΒ activator 2,NF-κB,ALS,amyotrophic,Nuclear factor-κB,lateral,NF κΒ activator 2,NFκΒ activator 2,NF-?B,Inhibitor,SOD2,sclerosis,inhibit | [Molecular Formula]
C16H11FN2O3 | [MOL File]
2375281-44-8.mol | [Molecular Weight]
298.27 |
| Chemical Properties | Back Directory | [Boiling point ]
512.1±60.0 °C(Predicted) | [density ]
1.396±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
3.89±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
NF-κΒ activator 2 is a potent and orally active NF-?B activator, with an EC50 of 1.58 μM. NF-κΒ activator 2 induces SOD2 through increasing NF-?B expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis (ALS)[1]. | [in vivo]
NF-κΒ activator 2 (1 mg/kg; i.v.) displays a suitable half-life (0.96 h) in mice[1].
NF-κΒ activator 2 (5 mg/kg; p.o.) displays a comparable half-life (2.86 h), oral bioavailability (15.6%), and Cmax (92 ng/mL)[1]. | [IC 50]
NF-κB: 1.58 μM (EC50) | [References]
[1] Mathew B, et, al. Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (SRI-22819) as NF-?B activators for the treatment of ALS. Eur J Med Chem. 2020 Oct 22;112952. DOI:10.1016/j.ejmech.2020.112952 |
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