| Identification | Back Directory | [Name]
NRMA-8 | [CAS]
2375659-15-5 | [Synonyms]
NRMA-8
Benzamide, 4-chloro-N-[2-[4-[1,1-dimethyl-2-(methylamino)-2-oxoethoxy]phenyl]ethyl]- | [Molecular Formula]
C20H23ClN2O3 | [MOL File]
2375659-15-5.mol | [Molecular Weight]
374.86 |
| Chemical Properties | Back Directory | [Boiling point ]
623.084±55.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.190±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
14.263±0.46(predicted) |
| Hazard Information | Back Directory | [Uses]
NRMA-8 is a brain-penetrant small molecule nuclear receptor modulator. NRMA-8 is promising for research of central nervous system disorders, including Alzheimer's disease, Parkinson's disease, demylenation disorders and glioblastomas[1][2]. | [References]
[1] SCANLAN Thomas S, et al. N-methyl amide prodrugs of small molecule nuclear receptor modulators. WO2019168842. 2018 March 02.
[2] Ferrara SJ, et al. A CNS-Targeting Prodrug Strategy for Nuclear Receptor Modulators. J Med Chem. 2020 Sep 10;63(17):9742-9751. DOI:10.1021/acs.jmedchem.0c00868 |
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