| Identification | Back Directory | [Name]
K-Ras ligand-Linker Conjugate 6 | [CAS]
2378261-89-1 | [Synonyms]
K-Ras ligand-Linker Conjugate 6
1-Piperazinecarboxylic acid, 4-[2-[[(2S,4R)-4-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]-1-methyl-2-pyrrolidinyl]methoxy]-5,6,7,8-tetrahydro-7-(1-naphthalenyl)pyrido[3,4-d]pyrimidin-4-yl]-2-(cyanomethyl)-, 1,1-dimethylethyl ester, (2S)- | [Molecular Formula]
C42H60N8O7 | [MDL Number]
MFCD32689654 | [MOL File]
2378261-89-1.mol | [Molecular Weight]
788.98 |
| Chemical Properties | Back Directory | [Boiling point ]
914.9±75.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [form ]
Oil | [pka]
8.74±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
K-Ras ligand-Linker Conjugate 6 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 6 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1]. | [References]
[1] CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2. |
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