| Identification | Back Directory | [Name]
2-[(2,4,5-Trihydroxyphenyl)methylene]-3(2H)-benzofuranone | [CAS]
2378406-17-6 | [Synonyms]
HA5
2-[(2,4,5-Trihydroxyphenyl)methylene]-3(2H)-benzofuranone | [Molecular Formula]
C15H10O5 | [MOL File]
2378406-17-6.mol | [Molecular Weight]
270.24 |
| Chemical Properties | Back Directory | [Boiling point ]
571.8±50.0 °C(Predicted) | [density ]
1.597±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [pka]
8.93±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
HA5 inhibits Streptococcus mutans biofilm with an IC50 value of 6.42 μM, without affecting its growth. HA5 also inhibits Streptococcus mutans glucan production and eDNA levels[1]. | [References]
[1] Ahirwar P, et al. Hydrogel-Encapsulated Biofilm Inhibitors Abrogate the Cariogenic Activity of Streptococcus mutans. J Med Chem. 2023 Jun 22;66(12):7909-7925. DOI:10.1021/acs.jmedchem.3c00272 |
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