| Identification | Back Directory | [Name]
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 11-(aminomethyl)-4-ethyl-8-fluoro-4-hydroxy-9-methyl-, (4S)- | [CAS]
2378616-23-8 | [Synonyms]
7-Aminomethyl-10-methyl-11-fluoro camptothecin
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 11-(aminomethyl)-4-ethyl-8-fluoro-4-hydroxy-9-methyl-, (4S)- | [Molecular Formula]
C22H20FN3O4 | [MOL File]
2378616-23-8.mol | [Molecular Weight]
409.41 |
| Chemical Properties | Back Directory | [Boiling point ]
802.4±65.0 °C(Predicted) | [density ]
1.51±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
11.19±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
7-Aminomethyl-10-methyl-11-fluoro camptothecin is a cytotoxin of MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin (HY-132158). 7-Aminomethyl-10-methyl-11-fluoro camptothecin can be used for the synthesis of camptothecin antibody-drug conjugate (ADC)[1]. | [References]
[1] Li W, et, al. Synthesis and Evaluation of Camptothecin Antibody-Drug Conjugates. ACS Med Chem Lett. 2019 Sep 6;10(10):1386-1392. DOI:10.1021/acsmedchemlett.9b00301 |
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