| Identification | Back Directory | [Name]
TED-347 | [CAS]
2378626-29-8 | [Synonyms]
TED-347
Ethanone, 2-chloro-1-[2-[[3-(trifluoromethyl)phenyl]amino]phenyl]- | [Molecular Formula]
C15H11ClF3NO | [MDL Number]
MFCD32689460 | [MOL File]
2378626-29-8.mol | [Molecular Weight]
313.7 |
| Chemical Properties | Back Directory | [Boiling point ]
378.0±42.0 °C(Predicted) | [density ]
1.352±0.06 g/cm3(Predicted) | [solubility ]
DMSO: 2 mg/mL, clear | [form ]
Solid | [pka]
-2.67±0.50(Predicted) | [color ]
Light yellow to green yellow | [InChI]
InChI=1S/C15H11ClF3NO/c16-9-14(21)12-6-1-2-7-13(12)20-11-5-3-4-10(8-11)15(17,18)19/h1-8,20H,9H2 | [InChIKey]
JPVDFGYNLUBCSD-UHFFFAOYSA-N | [SMILES]
C(=O)(C1=CC=CC=C1NC1=CC=CC(C(F)(F)F)=C1)CCl |
| Hazard Information | Back Directory | [Uses]
TED-347 is a potent, irreversible, covalent and allosteric inhibitor at YAP-TEAD protein-protein interaction with an EC50 of 5.9 μM for TEAD4?Yap1 protein-protein interaction. TED-347 specifically and covalently bonds with Cys-367 within the central pocket of TEAD4 with a Ki of 10.3 μM. TED-347 blocks TEAD transcriptional activity and has antitumor activity[1]. | [IC 50]
YAP/TAZ-TEAD | [References]
[1] Khuchtumur Bum-Erdene, et al. Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD?Yap Protein-Protein Interaction. Cell Chem Biol. 2019 Mar 21;26(3):378-389.e13. DOI:10.1016/j.chembiol.2018.11.010 |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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