| Identification | Back Directory | [Name]
Boronic acid, B-[2-methoxy-3-(3,8,9,10-tetrahydrocyclopenta[c]pyrazolo[4,3-f]quinolin-7-yl)phenyl]- | [CAS]
2379279-96-4 | [Synonyms]
HSD1590
Boronic acid, B-[2-methoxy-3-(3,8,9,10-tetrahydrocyclopenta[c]pyrazolo[4,3-f]quinolin-7-yl)phenyl]- | [Molecular Formula]
C20H18BN3O3 | [MDL Number]
MFCD32708513 | [MOL File]
2379279-96-4.mol | [Molecular Weight]
359.19 |
| Chemical Properties | Back Directory | [Boiling point ]
676.2±65.0 °C(Predicted) | [density ]
1.43±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
7.83±0.58(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
HSD1590 is potent ROCK inhibitor, with IC50s of 1.22 and 0.51 nM for ROCK1 and ROCK2, respectively. HSD1590 exhibits single digit nanomolar binding to ROCK (Kds<2 nM). HSD1590 displays low cytotoxicity[1]. | [IC 50]
ROCK1: 1.22 nM (IC50); ROCK2: 0.51 nM (IC50) | [References]
[1] Dayal N, et al. Potently inhibiting cancer cell migration with novel 3H-pyrazolo[4,3-f]quinoline boronic acid ROCK inhibitors. Eur J Med Chem. 2019 Oct 15;180:449-456. DOI:10.1016/j.ejmech.2019.06.089 |
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