| Identification | Back Directory | [Name]
β-NF-JQ1 | [CAS]
2380000-55-3 | [Synonyms]
β-NF-JQ1
β-NF-JQ1
6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-2,3,9-trimethyl-N-[2-[2-[2-[[4-(1-oxo-1H-naphtho[2,1-b]pyran-3-yl)phenyl]methoxy]ethoxy]ethoxy]ethyl]-, (6S)- | [Molecular Formula]
C45H42ClN5O6S | [MDL Number]
MFCD32263055 | [MOL File]
2380000-55-3.mol | [Molecular Weight]
816.36 |
| Hazard Information | Back Directory | [Uses]
β-NF-JQ1 is a PROTAC that recruits Aryl Hydrocarbon Receptor E3 ligase to target proteins. β-NF-JQ1 is directed against bromodomain-containing (BRD) proteins using β-NF as an AhR ligand, induces the interaction of AhR and BRD proteins, and displays effective anticancer activity that correlated with protein knockdown activity[1]. | [References]
[1] Ohoka N, et al. Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins. ACS Chem Biol. 2019 Oct 16. DOI:10.1021/acschembio.9b00704 |
|
|