| Identification | Back Directory | [Name]
INDEX NAME NOT YET ASSIGNED | [CAS]
2380321-51-5 | [Synonyms]
PF-07220060
CDK4/6-IN-6
CDK4/6-IN-6CDK4/CDK4/6-IN-66-IN-6
1,5-anhydro-3-((5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1 H-benzimidazol-6- yl]pyrimidin-2-yl)amino)-2,3-dideoxy-D-threo-pentitol | [Molecular Formula]
C22H27ClFN5O3 | [MOL File]
2380321-51-5.mol | [Molecular Weight]
463.94 |
| Chemical Properties | Back Directory | [Boiling point ]
687.4±65.0 °C(Predicted) | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 250 mg/mL (538.87 mM; Need ultrasonic) | [form ]
Solid | [pka]
13.43±0.29(Predicted) | [color ]
White to off-white | [InChIKey]
QYJLBHRAPDJOSO-JBKWZTHDNA-N | [SMILES]
C(N1C(=NC2=C(C=C(C3C(=CN=C(N[C@@H]4CCOC[C@H]4O)N=3)Cl)C=C12)F)C(O)(C)C)(C)C |&1:14,19,r| |
| Hazard Information | Back Directory | [Biological Activity]
CDK4/6-IN-6 (example A94) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively[1].
CDK4/6-IN-6 (example A94) has IC50s of 38.5 nM and 144.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3 using phospho-Rb S795 ELISA assays in JEKO-1 and MV4-1 1 cells[1]. | [References]
[1]. Ping Chen, et al. 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors. WO2019207463A1. |
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