| Chemical Properties | Back Directory | [Melting point ]
151-153 °C | [Boiling point ]
581.9±50.0 °C(predicted) | [density ]
1.23±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
15.66±0.46(predicted) |
| Hazard Information | Back Directory | [Uses]
Topoisomerase II inhibitor 18 (Compound IV) is a Quinoxaline derivative, which inhibits topoisomerase II with IC50 of 7.5 μM. Topoisomerase II inhibitor 18 inhibits proliferation, cell cycle at S phase and induces apoptosis in PC-3 cells. Topoisomerase II inhibitor 18 reveals antitumor activity against cancer[1]. | [in vivo]
Topoisomerase II inhibitor 18 (5 mg/kg, i.m. for 21 days) exhibits antitumor activity in Ehrlich solid tumor bearing albino mice, exhibits kidney protective efficacy[1]. | Animal Model: | Ehrlich solid tumor bearing albino mice[1] | | Dosage: | 5 mg/kg | | Administration: | i.m. for 21 days | | Result: | Inhibited tumor growth. |
| [IC 50]
Topoisomerase II: 7.5 μM (IC50) | [References]
[1] Elsakka MEG, et al., A quinoxaline-based derivative exhibited potent and selective anticancer activity with apoptosis induction in PC-3 cells through Topo II inhibition. J Biomol Struct Dyn. 2024 Mar 14:1-19. DOI:10.1080/07391102.2024.2327538 |
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