| Identification | Back Directory | [Name]
2-Piperidinecarboxylic acid, 1-(3,3-dimethyl-1,2-dioxopentyl)-, (1R)-1-[3-[[3-[2-[2-[[2-[[1-(2-chloroacetyl)-1,2,3,4-tetrahydro-6-quinolinyl]oxy]acetyl]amino]ethoxy]ethoxy]-1-oxopropyl]amino]phenyl]-3-(3,4-dimethoxyphenyl)propyl ester, (2S)- | [CAS]
2384184-40-9 | [Synonyms]
KB02-SLF
2-Piperidinecarboxylic acid, 1-(3,3-dimethyl-1,2-dioxopentyl)-, (1R)-1-[3-[[3-[2-[2-[[2-[[1-(2-chloroacetyl)-1,2,3,4-tetrahydro-6-quinolinyl]oxy]acetyl]amino]ethoxy]ethoxy]-1-oxopropyl]amino]phenyl]-3-(3,4-dimethoxyphenyl)propyl ester, (2S)- | [Molecular Formula]
C50H65ClN4O12 | [MOL File]
2384184-40-9.mol | [Molecular Weight]
949.52 |
| Chemical Properties | Back Directory | [density ]
1.240±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, away from moisture and light | [solubility ]
DMSO : 100 mg/mL (105.32 mM; Need ultrasonic) | [form ]
Solid | [pka]
14.03±0.46(Predicted) | [color ]
White to yellow | [InChIKey]
OKJBKEQXKMMRPL-WVILEFPPSA-N | [SMILES]
O=C(CCl)N1CCCC2=CC(OCC(NCCOCCOCCC(NC3=CC=CC([C@H](OC([C@@H]4CCCCN4C(C(C(C)(C)CC)=O)=O)=O)CCC5=CC(OC)=C(OC)C=C5)=C3)=O)=O)=CC=C21 |
| Hazard Information | Back Directory | [Uses]
KB02-SLF is a PROTAC-based nuclear FKBP12 degrader (molecular glue). KB02-SLF promotes nuclear FKBP12 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. SLF binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-SLF[1]. | [References]
[1] Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15(7):737-746. DOI:10.1038/s41589-019-0279-5 |
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|