| Chemical Properties | Back Directory | [density ]
1.424±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
6.010±0.10(predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
DZD1516 is a potent and selective HER2 inhibitor (IC50=0.56 nM) with good blood-brain permeability. DZD1516 exhibits antitumor activity in CNS and subcutaneous xenograft mouse models[1]. | [References]
[1] Zhang J, et al. Preclinical and clinical activity of DZD1516, a full blood-brain barrier-penetrant, highly selective HER2 inhibitor. Breast Cancer Res. 2023 Jul 6;25(1):81. DOI:10.1186/s13058-023-01679-4 |
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