| Identification | Back Directory | [Name]
4-Quinolinamine, 6-(4-aminophenyl)-N-[3-(1H-imidazol-1-yl)propyl]-3-(1,3,4-oxadiazol-2-yl)- | [CAS]
2393082-56-7 | [Synonyms]
Topoisomerase I inhibitor 6
4-Quinolinamine, 6-(4-aminophenyl)-N-[3-(1H-imidazol-1-yl)propyl]-3-(1,3,4-oxadiazol-2-yl)- | [Molecular Formula]
C23H21N7O | [MOL File]
2393082-56-7.mol | [Molecular Weight]
411.46 |
| Hazard Information | Back Directory | [Uses]
Topoisomerase I inhibitor 6 (Compound 3) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 6 is able to trap DNA-Top1 cleavage complex and found to be less cytotoxic in non-cancerous cell line. Topoisomerase I inhibitor 6 has the potential for the research of cancer diseases[1]. | [References]
[1] Kundu B, et al. Development of a metabolically stable topoisomerase I poison as anticancer agent. Eur J Med Chem. 2020 Sep 15;202:112551. doi: 10.1016/j.ejmech.2020.112551. DOI:10.1016/j.ejmech.2020.112551 |
|
|