| Chemical Properties | Back Directory | [Boiling point ]
866.4±65.0 °C(Predicted) | [density ]
1.222±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
A solid | [pka]
3.50±0.10(Predicted) | [Sequence]
Tyr-{D-Val}-Val-{D-Phe} |
| Hazard Information | Back Directory | [Uses]
Bilaid C, a tetrapeptide, can be isolated from the Australian estuarine isolate of Penicillium sp. MST-MF667. Bilaid C is also a potent and selective μ-Opioid Receptor (MOPr) agonist (Ki=210 nM, hMOPr)[1]. | [Biological Activity]
Bilaid C is a tetrapeptide μ-opioid receptor agonist (Ki = 210 nM in HEK293 cell membranes expressing the human receptor) that has been found in Penicillium.1 It inhibits forskolin-induced cAMP accumulation by 77% in HEK293 cells expressing the human μ-opioid receptor when used at a concentration of 10 μM. Bilaid C induces inward rectifying potassium channel (Kir) currents in rat locus coeruleus slices that endogenously express high levels of the μ-opioid receptor (EC50 = 4.2 μM). | [IC 50]
human μ-opioid receptor: 210 nM (Ki) | [storage]
Store at -20°C | [References]
1.Dekan, Z., Sianati, S., Yousuf, A., et al.A tetrapeptide class of biased analgesics from an Australian fungus targets the μ-opioid receptorProc. Natl. Acad. Sci. USA116(44)22353-22358(2019)
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BOC Sciences
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1-631-485-4226; 16314854226 |
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https://www.bocsci.com |
| Company Name: |
ChemeGen
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18818260767 |
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https://www.chemegen.com |
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