| Identification | Back Directory | [Name]
Indeno[2,1-c]pyrazol-8(1H)-one, 1-(4-methylphenyl)- | [CAS]
2393928-76-0 | [Synonyms]
HIF-IN-1
Indeno[2,1-c]pyrazol-8(1H)-one, 1-(4-methylphenyl)- | [Molecular Formula]
C17H12N2O | [MOL File]
2393928-76-0.mol | [Molecular Weight]
260.29 |
| Chemical Properties | Back Directory | [Boiling point ]
444.6±24.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
-2.41±0.20(Predicted) | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Uses]
HIF-IN-1 (Compound 3c) is a hypoxia-inducible factor (HIF)-1 inhibitor. HIF-IN-1 suppresses HIF-1α protein accumulation without affecting the levels of HIF-1α mRNA. HIF-IN-1 shows no obvious cytotoxicity[1]. | [References]
[1] Fuse S, et al. Design, synthesis, and evaluation of indeno[2,1-c]pyrazolones for use as inhibitors against hypoxia-inducible factor (HIF)-1 transcriptional activity. Bioorg Med Chem. 2020 Jan 1;28(1):115207. DOI:10.1016/j.bmc.2019.115207 |
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