| Identification | Back Directory | [Name]
4-Isothiazolecarbonitrile, 2,3-dihydro-5-[(6-methoxy-2-methyl-5-quinolinyl)amino]-2-methyl-3-oxo- | [CAS]
2396592-52-0 | [Synonyms]
SARM1-IN-2
4-Isothiazolecarbonitrile, 2,3-dihydro-5-[(6-methoxy-2-methyl-5-quinolinyl)amino]-2-methyl-3-oxo- | [Molecular Formula]
C16H14N4O2S | [MOL File]
2396592-52-0.mol | [Molecular Weight]
326.37 |
| Chemical Properties | Back Directory | [Boiling point ]
477.7±55.0 °C(Predicted) | [density ]
1.42±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
6.04±0.50(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
SARM1-IN-2 (Example 82) is a SARM1 inhibitor with an IC50 value of <1 μM. SARM1-IN-2 inhibits axonal regrowth, leading to only 6% regrowth after 72?h of exposure. SARM1-IN-2 can be used for the research of axonal degeneration[1]. | [References]
[1] Hughes RO, et, al. Inhibitors of sarm1. WO2019236890A1.
[2] Bonneau N, et al. Assessment of corneal nerve regeneration after axotomy in a compartmentalized microfluidic chip model with automated 3D high resolution live-imaging. Front Cell Neurosci. 2024 Jul 15;18:1417653. DOI:10.3389/fncel.2024.1417653 |
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