ChemicalBook--->CAS DataBase List--->2396664-85-8

2396664-85-8

Request For Quotation
2396664-85-8 Structure

2396664-85-8 Structure
IdentificationBack Directory
[Name]

2-Propenamide, N-[2-[[3-(3,5-dimethoxybenzoyl)-1H-pyrrolo[2,3-b]pyridin-6-yl]amino]-5-(4-morpholinyl)phenyl]-
[CAS]

2396664-85-8
[Synonyms]

FGFR4-IN-11
2-Propenamide, N-[2-[[3-(3,5-dimethoxybenzoyl)-1H-pyrrolo[2,3-b]pyridin-6-yl]amino]-5-(4-morpholinyl)phenyl]-
[Molecular Formula]

C29H29N5O5
[MOL File]

2396664-85-8.mol
[Molecular Weight]

527.57
Chemical PropertiesBack Directory
[density ]

1.334±0.06 g/cm3(Predicted)
[pka]

12.49±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

FGFR4-IN-11 (Compound 30) is a potent, selective, covalent FGFR4 inhibitor with an IC50 of 2.1 nM. FGFR4-IN-11 significantly inhibits the FGF19/FGFR4 signaling pathway and shows antitumor activity[1].
[IC 50]

FGFR4: 2.1 nM (IC50)
[References]

[1] Zhong Z, et al. Discovery of Novel 7-Azaindole Derivatives as Selective Covalent Fibroblast Growth Factor Receptor 4 Inhibitors for the Treatment of Hepatocellular Carcinoma. J Med Chem. 2022 May 26;65(10):7278-7295. DOI:10.1021/acs.jmedchem.2c00255
2396664-85-8 suppliers list
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Telephone: 13816613772
Website: https://www.chemicalbook.com/ShowSupplierProductsList16976/0_EN.htm
Company Name: TargetMol Chemicals Inc.  
Telephone: 15002134094
Website: https://www.targetmol.cn/
Tags:2396664-85-8 Related Product Information
1448169-71-8 485-72-3