| Identification | Back Directory | [Name]
Isothiazolo[4,3-b]pyridine, 5-(3,4-dimethoxyphenyl)-3-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-, rel- | [CAS]
2396706-31-1 | [Synonyms]
GAK inhibitor 2
Isothiazolo[4,3-b]pyridine, 5-(3,4-dimethoxyphenyl)-3-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-, rel- | [Molecular Formula]
C20H23N3O3S | [MOL File]
2396706-31-1.mol | [Molecular Weight]
385.48 |
| Chemical Properties | Back Directory | [Boiling point ]
549.3±50.0 °C(Predicted) | [density ]
1.219±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
6.80±0.50(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
GAK inhibitor 2 (Compound 14g) is a potent cyclin G-associated kinase (GAK) inhibitor with an IC50 of 0.024 μM. GAK inhibitor 2 shows antiviral activity with an EC50 of 1.049 μM against dengue virus (DENV)[1]. | [References]
[1] Martinez-Gualda B, et al. Structure-activity relationship study of the pyridine moiety of isothiazolo[4,3-b]pyridines as antiviral agents targeting cyclin G-associated kinase. Bioorg Med Chem. 2020 Jan 1;28(1):115188. DOI:10.1016/j.bmc.2019.115188 |
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