| Chemical Properties | Back Directory | [Boiling point ]
537.0±52.0 °C(Predicted) | [density ]
1.880±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml | [form ]
A crystalline solid | [pka]
3.11±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CU-32 is a potent cGAS inhibitor with an IC50 of 0.45 μM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells[1]. | [Biological Activity]
CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS; IC50 = 0.45 μM).1 It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. It is also selective for cGAS over toll-like receptors (TLRs) at 50 μM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 μM. | [storage]
Store at -20°C | [References]
1.Padilla-Salinas, R., Sun, L., Anderson, R., et al.Discovery of small-molecule cyclic GMP-AMP synthase inhibitorsJ. Org. Chem.85(3)1579-1600(2020)
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| Company Name: |
ChemeGen
|
| Tel: |
18818260767 |
| Website: |
https://www.chemegen.com |
| Company Name: |
Cellosaurus STR
|
| Tel: |
13121892008 |
| Website: |
www.cellosaurus.org |
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