| Identification | Back Directory | [Name]
t-Boc-Aminooxy-PEG4-NHS ester | [CAS]
2401831-99-8 | [Synonyms]
t-Boc-Aminooxy-PEG4-NHS ester | [Molecular Formula]
C20H34N2O11 | [MDL Number]
MFCD32670307 | [MOL File]
2401831-99-8.mol | [Molecular Weight]
478.49 |
| Chemical Properties | Back Directory | [density ]
1.24±0.1 g/cm3(Predicted) | [storage temp. ]
Storage temp. -20°C | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Viscous Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
t-Boc-Aminooxy-PEG4-NHS ester is an active NHS ester which can react with amino(NH2)-containing molecule. The t-Boc can be removed under mild acidic condition to free the aminooxy group, which can react with aldehyde moiety.. | [Uses]
t-Boc-Aminooxy-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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