| Identification | Back Directory | [Name]
2403729-27-9 | [CAS]
2403729-27-9 | [Synonyms]
Topoisomerase II inhibitor 16
1H-1,2,4-Triazole-3-carbonitrile, 1-[2-[1,3-dihydro-5-[2-(trifluoromethyl)-3-pyridinyl]-2H-isoindol-2-yl]-2-oxoethyl]- (ACI)
1H-1,2,4-Triazole-3-carbonitrile, 1-[2-[5-[5-fluoro-2-(trifluoromethyl)-3-pyridinyl]-1,3-dihydro-2H-isoindol-2-yl]-2-oxoethyl]- (ACI) | [Molecular Formula]
C19H12F4N6O | [MOL File]
2403729-27-9.mol | [Molecular Weight]
416.33 |
| Chemical Properties | Back Directory | [Boiling point ]
607.837±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.537±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [solubility ]
DMF: 25 mg/ml
DMSO: 15 mg/ml
Ethanol: Slightly soluble | [pka]
0.264±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
Topoisomerase II inhibitor 16 (compound CT3) is a selective, orally active, brain-penetrant and irreversible trypanosomal topoisomerase II inhibitor by stabilizing double-stranded DNA:enzyme cleavage complexes. Topoisomerase II inhibitor 16 has the potential for Chagas disease research[1]. | [References]
[1] Srinivasa P S Rao, et al. Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science. 2023 Jun 30;380(6652):1349-1356. DOI:10.1126/science.adh0614 |
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