| Chemical Properties | Back Directory | [Boiling point ]
968.4±65.0 °C(predicted) | [density ]
1.511±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
10.75±0.40(predicted) |
| Hazard Information | Back Directory | [Uses]
PROTAC BRD4 Degrader-27 (compound 6b) is a PROTAC that selectively targets BRD4 (rather than BRD2/BRD3) and can also inhibit the expression of KLF5 transcription factor and exert anti-cancer activity. PROTAC BRD4 Degrader-27 is composed of E3 ubiquitinase ligand Thalidomide-4-OH (HY-103596) (red part), PROTAC Linker γ-Aminobutyric acid (HY-N0067) (black part) and PROTAC target protein ligand PROTAC BRD4 ligand-3 (HY-162876) (blue part), of which the active control of the target protein ligand is Mivebresib (HY-100015), and the conjugate of E3 ubiquitin ligase ligand + Linker is Pomalidomide 4'-alkylC3-acid (HY-131875)[1]. | [References]
[1] Kong Y, et al. BRD4-specific PROTAC inhibits basal-like breast cancer partially through downregulating KLF5 expression. Oncogene. 2024 Sep;43(39):2914-2926. DOI:10.1038/s41388-024-03121-1 |
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