| Identification | Back Directory | [Name]
Benzoic acid, 2-[[7-[4-(aminosulfonyl)phenyl]-5-(4-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]- | [CAS]
2408599-78-8 | [Synonyms]
hCAII-IN-2
Benzoic acid, 2-[[7-[4-(aminosulfonyl)phenyl]-5-(4-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]- | [Molecular Formula]
C25H18ClN5O4S | [MOL File]
2408599-78-8.mol | [Molecular Weight]
519.96 |
| Hazard Information | Back Directory | [Uses]
hCAII-IN-2 (Compound 11f) is a cytosolic human carbonic anhydrase (hCA) inhibitor with Ki values of 261.4, 3.8, 19.6 and 45.2 nM against hCA I, hCA II, hCA IX and hCA XII, respectively[1]. | [References]
[1] Khalil OM, et al. Pyrrolo and pyrrolopyrimidine sulfonamides act as cytotoxic agents in hypoxia via inhibition of transmembrane carbonic anhydrases. Eur J Med Chem. 2020 Feb 15;188:112021. DOI:10.1016/j.ejmech.2019.112021 |
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