| Identification | Back Directory | [Name]
Mal-PEG4-Glu(TFP ester)-NH-m-PEG24 | [CAS]
2408741-87-5 | [Synonyms]
Mal-PEG4-Glu(TFP ester)-NH-m-PEG24
MAL-dPEG??-Glu(TFP ester)-NH-m-dPEG??? | [Molecular Formula]
C78H134F4N4O35 | [MDL Number]
MFCD31657174 | [MOL File]
2408741-87-5.mol | [Molecular Weight]
1763.9 |
| Hazard Information | Back Directory | [Uses]
Mal-PEG4-Glu(TFP ester)-NH-m-PEG24 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [Biological Activity]
Mal-PEG4-Glu(TFP ester)-NH-m-PEG24 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [IC 50]
PEGs | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
|
|