| Hazard Information | Back Directory | [Uses]
RGH-560 (compound 53) shows highly advanced α7 nAChR positive modulator properties and favorable physicochemical features. RGH-560 has robust procognitive in vivo potential. RGH-560 can be used to study Scopolamine (HY-N0296) -induced amnesia in mice[1]. | [in vivo]
RGH-560 (compound 53) (1 mg/kg, 3 mg/kg, 10 mg/kg; Intraperitoneal injection) has significant cognitive-enhancement in Scopolamine(HY-N0296)-induced amnesia in mice. RGH-560 is a medium clearance compound. RGH-560 is non-toxic to mice at doses up to 30 mg/kg[1].
| Animal Model: | Mice with scopolamine-induced amnesia[1] | | Dosage: | 1 mg/kg, 3 mg/kg, 10 mg/kg | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Reversed the scopolamine-induced cognitive impairment. |
| [References]
[1] Ledneczki I, et al. Optimization of Novel α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators and the Discovery of a Preclinical Development Candidate Molecule (RGH-560). Journal of Medicinal Chemistry. 2023 Nov. DOI:10.1021/acs.jmedchem.3c01635 |
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