| Identification | Back Directory | [Name]
Fmoc-L-Lys(Pentynoyl-DIM)-OH | [CAS]
2408993-33-7 | [Synonyms]
Fmoc-L-Lys(Pentynoyl-DIM)-OH
L-Lysine, N6-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-4-pentyn-1-yl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]- | [Molecular Formula]
C34H38N2O6 | [MOL File]
2408993-33-7.mol | [Molecular Weight]
570.68 |
| Hazard Information | Back Directory | [Uses]
Fmoc-L-Lys(Pentynoyl-DIM)-OH is a click chemistry reagent containing an azide. Fmoc-L-Lys(Pentynoyl-DIM)-OH can be used as a SPPS building block for the “helping hand” strategy for purification of highly insoluble peptides. Solubilizing residues are attached to the Lys side-chains using Click-chemistry. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. | [References]
[1] Meng G, et al. Modular click chemistry libraries for functional screens using a diazotizing reagent. Nature. 2019 Oct;574(7776):86-89. DOI:10.1038/s41586-019-1589-1 |
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