| Identification | Back Directory | [Name]
L-Prolinamide, N-[7-[4-[6-[[2-[(4-fluorophenyl)amino]-4-[4-(hydroxymethyl)-1-piperidinyl]pyrido[3,4-d]pyrimidin-6-yl]amino]-3-pyridinyl]-1-piperazinyl]-1-oxoheptyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- | [CAS]
2409793-36-6 | [Synonyms]
L-Prolinamide, N-[7-[4-[6-[[2-[(4-fluorophenyl)amino]-4-[4-(hydroxymethyl)-1-piperidinyl]pyrido[3,4-d]pyrimidin-6-yl]amino]-3-pyridinyl]-1-piperazinyl]-1-oxoheptyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- | [Molecular Formula]
C57H72FN13O5S | [MOL File]
2409793-36-6.mol | [Molecular Weight]
1070.33 |
| Hazard Information | Back Directory | [Uses]
PROTAC EGFR degrader 5 (Compound 10), a PROTAC EGFR degrader, potently degrades EGFRDel19 in HCC827 cells with the DC50 of 34.8 nM. PROTAC EGFR degrader 5 significantly induces the apoptosis of HCC827 cells and arrest the cells in G1 phase[1]. | [IC 50]
EGFR: 34.8 nM (DC50) | [References]
[1] Hao Zhang, et al. Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC). Eur J Med Chem. 2020 Mar 1;189:112061. DOI:10.1016/j.ejmech.2020.112061 |
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