| Identification | Back Directory | [Name]
Thieno[2′,3′:4,5]pyrrolo[1,2-d][1,2,4]triazine-7(8H)-acetamide, 2-chloro-N-[(3R)-1-(cyclopropylmethyl)-3-piperidinyl]-5-(1-methylethyl)-8-oxo- | [CAS]
2409826-23-7 | [Synonyms]
Thieno[2′,3′:4,5]pyrrolo[1,2-d][1,2,4]triazine-7(8H)-acetamide, 2-chloro-N-[(3R)-1-(cyclopropylmethyl)-3-piperidinyl]-5-(1-methylethyl)-8-oxo- | [Molecular Formula]
C22H28ClN5O2S | [MOL File]
2409826-23-7.mol | [Molecular Weight]
462.01 |
| Hazard Information | Back Directory | [Uses]
NIC-12 is a potent NLRP3 inhibitor. NIC-12 selectively reduces circulating IL-1? levels in the LPS-endotoxemia mice model. NIC-12 inhibits NLRP3 inflammasome activation in mouse macrophages[1]. | [References]
[1] Vande Walle L, et al. Novel chemotype NLRP3 inhibitors that target the CRID3-binding pocket with high potency. Life Sci Alliance. 2024 Mar 22;7(6):e202402644. DOI:10.26508/lsa.202402644 |
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