| Identification | Back Directory | [Name]
Benzenesulfonamide, 4-[(1E)-2-[6-amino-2-(4-methylphenyl)-1H-imidazo[1,2-b]pyrazol-7-yl]diazenyl]- | [CAS]
2410402-75-2 | [Synonyms]
Carbonic anhydrase inhibitor 14
Benzenesulfonamide, 4-[(1E)-2-[6-amino-2-(4-methylphenyl)-1H-imidazo[1,2-b]pyrazol-7-yl]diazenyl]- | [Molecular Formula]
C18H17N7O2S | [MOL File]
2410402-75-2.mol | [Molecular Weight]
395.44 |
| Hazard Information | Back Directory | [Uses]
Carbonic anhydrase inhibitor 14 (Compound 8b) is a carbonic anhydrase (CA) inhibitor with Ki values of 1203, 99.7, 9.4 and 27.7 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 14 can also inhibit CDK2 with an IC50 of 20.3 μM. Carbonic anhydrase inhibitor 14 shows antitumor activity[1]. | [IC 50]
CDK2: 20.3 μM (IC50); hCA XII: 27.7 nM (Ki); hCA IX: 9.4 nM (Ki); hCA II: 99.7 nM (Ki); hCA I: 1203 nM (Ki) | [References]
[1] Said MA, et al. Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation. Eur J Med Chem. 2020 Mar 1;189:112019. DOI:10.1016/j.ejmech.2019.112019 |
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