Identification | Back Directory | [Name]
Phenol, 4-[5-[[[2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)ethyl]amino]methyl]-2-furanyl]- | [CAS]
2411088-16-7 | [Synonyms]
5-HT6/5-HT2A receptor ligand-2 Phenol, 4-[5-[[[2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)ethyl]amino]methyl]-2-furanyl]- | [Molecular Formula]
C20H18FN3O2 | [MOL File]
2411088-16-7.mol | [Molecular Weight]
351.37 |
Hazard Information | Back Directory | [Uses]
5-HT6/5-HT2A receptor ligand-2 (compound 42) is a brain-penetrant dual 5-HT6/5-HT2A receptor antagonist, with a Ki of 25 nM and?32?nM, respectively. 5-HT6/5-HT2A receptor ligand-2 shows pro-cognitive properties[1]. | [IC 50]
5-HT6 Receptor: 25 nM (Ki); 5-HT2A Receptor: 32 nM (Ki) | [References]
[1] Staroń J, et, al. Virtual screening-driven discovery of dual 5-HT 6/5-HT 2A receptor ligands with pro-cognitive properties. Eur J Med Chem. 2020 Jan 1;185:111857. DOI:10.1016/j.ejmech.2019.111857 |
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