| Identification | Back Directory | [Name]
9(10H)-Acridinone, 2-methoxy-5,6-dimethyl- | [CAS]
2411100-70-2 | [Synonyms]
STING Agonist 12b
9(10H)-Acridinone, 2-methoxy-5,6-dimethyl- | [Molecular Formula]
C16H15NO2 | [MOL File]
2411100-70-2.mol | [Molecular Weight]
253.3 |
| Chemical Properties | Back Directory | [Boiling point ]
445.2±45.0 °C(Predicted) | [density ]
1.177±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 1 mg/ml,DMSO: 1 mg/ml | [form ]
A crystalline solid | [pka]
0.53±0.50(Predicted) |
| Hazard Information | Back Directory | [Uses]
STING agonist-14 (compound 12b) is a potent STING agonist that is efficacious across species. STING agonist-14 could activate the pathway by directly binding human STING. STING agonist-14 can be used for the research of tumours or viral infections[1]. | [Biological Activity]
STING agonist 12b is an agonist of stimulator of interferon genes (STING).1 It binds to STING (Kd = 26.4 μM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 μM, respectively). STING agonist 12b (40 μM) induces expression of TNF-a, IL-6, IP-10, and IL-1b in THP-1 cells. | [References]
1.Hou, S., Lan, X.-j., Li, W., et al.Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonistsBioorg. Chem.95103556(2020)
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