| Identification | Back Directory | [Name]
5H-Quinindoline, 2-chloro-8-methoxy-5-methyl- | [CAS]
2411108-21-7 | [Synonyms]
5H-Quinindoline, 2-chloro-8-methoxy-5-methyl- | [Molecular Formula]
C17H13ClN2O | [MOL File]
2411108-21-7.mol | [Molecular Weight]
296.75 |
| Chemical Properties | Back Directory | [Melting point ]
180.11-181.23 °C | [Boiling point ]
483.9±55.0 °C(predicted) | [density ]
1.33±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
6.26±0.20(predicted) |
| Hazard Information | Back Directory | [Uses]
Anticancer agent 235 (Compound 49) is a modulator for PI3K/AKT/mTOR pathway, that promotes the generation of ROS, reduces the mitochondrial membrane potential, and thereby inhibits the proliferation of cancer cells HCT116, Caco-2, AGS and SMMC-772 with IC50 of 0.35-26.9 μM. Anticancer agent 235 arrests the cell cycle at G2/M phase, and induces apoptosis in HCT116[1]. | [References]
[1] Ma Y, et al. Synthesis and Biological Activity of 2-Chloro-8-methoxy-5-methyl-5 H-indolo [2, 3-b] Quinoline for the Treatment of Colorectal Cancer by Modulating PI3K/AKT/mTOR Pathways[J]. ACS Omega, 2024. |
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