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2411390-10-6

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2411390-10-6 Structure

2411390-10-6 Structure
IdentificationBack Directory
[Name]

L-Tryptophan, 1-[4-chloro-6-(1-piperidinyl)-1,3,5-triazin-2-yl]-, methyl ester
[CAS]

2411390-10-6
[Synonyms]

COX-2-IN-17
L-Tryptophan, 1-[4-chloro-6-(1-piperidinyl)-1,3,5-triazin-2-yl]-, methyl ester
[Molecular Formula]

C20H23ClN6O2
[MOL File]

2411390-10-6.mol
[Molecular Weight]

414.89
Chemical PropertiesBack Directory
[Boiling point ]

641.7±63.0 °C(Predicted)
[density ]

1.45±0.1 g/cm3(Predicted)
[pka]

6.82±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

COX-2-IN-17 (compound 10) is a potent and BBB-penetrated COX-2 (cyclooxygenase-2) inhibitor, with an IC50 of 0.02 μM. COX-2-IN-17 shows anti-inflammatory and analgesic activities. COX-2-IN-17 attenuates hyperalgesia in the neurogenic phase as well as the inflammatory phase[1].
[IC 50]

COX-2: 0.02 μM (IC50); COX-1: >10 μM (IC50)
[References]

[1] Kumari P, et al. Modification of the lead molecule: Tryptophan and piperidine appended triazines reversing inflammation and hyeperalgesia in rats. Bioorg Med Chem. 2020 Jan 15;28(2):115246. DOI:10.1016/j.bmc.2019.115246
2411390-10-6 suppliers list
Company Name: TargetMol Chemicals Inc.  
Telephone: 15002134094
Website: https://www.targetmol.cn/
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