| Identification | Back Directory | [Name]
1H-Benzimidazole-1-acetamide, N-(2,3-dihydro-1H-inden-5-yl)-2-[2-[(phenylsulfonyl)amino]ethyl]- | [CAS]
2411441-54-6 | [Synonyms]
NOD2 antagonist 1
1H-Benzimidazole-1-acetamide, N-(2,3-dihydro-1H-inden-5-yl)-2-[2-[(phenylsulfonyl)amino]ethyl]- | [Molecular Formula]
C26H26N4O3S | [MOL File]
2411441-54-6.mol | [Molecular Weight]
474.58 |
| Hazard Information | Back Directory | [Description]
NOD2 antagonist 1 (compound 32) is a potent and selective NOD2 antagonist with an IC50 of 5.23 μM. NOD2 antagonist 1 inhibits Muramyl dipeptide (MDP)-induced IL-8 secretion in THP-1 cells and inhibits MDP-induced IL-6, IL-10, TNF-α release in PBMCs[1]. | [Uses]
NOD2 antagonist 1 (compound 32) is a potent and selective NOD2 antagonist with an IC50 of 5.23 μM. NOD2 antagonist 1 inhibits Muramyl dipeptide (MDP)-induced IL-8 secretion in THP-1 cells and inhibits MDP-induced IL-6, IL-10, TNF-α release in PBMCs[1]. | [IC 50]
NOD2: 5.23 μM (IC50) | [storage]
Store at -20°C | [References]
[1] Guzelj S, et al. Structural features and functional activities of benzimidazoles as NOD2 antagonists. Eur J Med Chem. 2020;190:112089. DOI:10.1016/j.ejmech.2020.112089 |
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