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2411741-01-8

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2411741-01-8 Structure

2411741-01-8 Structure
IdentificationBack Directory
[Name]

4H-1-Benzopyran-4-one, 5-(1-azetidinylmethyl)-6-hydroxy-2-(4-hydroxyphenyl)-
[CAS]

2411741-01-8
[Synonyms]

Antituberculosis agent-2
4H-1-Benzopyran-4-one, 5-(1-azetidinylmethyl)-6-hydroxy-2-(4-hydroxyphenyl)-
[Molecular Formula]

C19H17NO4
[MOL File]

2411741-01-8.mol
[Molecular Weight]

323.34
Chemical PropertiesBack Directory
[Boiling point ]

565.4±50.0 °C(Predicted)
[density ]

1.424±0.06 g/cm3(Predicted)
[pka]

8.88±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

Antituberculosis agent-2 (Compound 8d) is an antituberculosis agent against agent-sensitive and multidrug-resistant tuberculosis. Antituberculosis agent-2 shows anti-tuberculosis activity with MIC values of 0.454, 1.757 and 1.644 μg/mL against M. tuberculosis H37Rv, 13946 and 14862, respectively. Antituberculosis agent-2 displays favorable mouse and human microsomal stability, low cytotoxicity, and acceptable oral bioavailability[1].
[References]

[1] Zhao W, et al. Design, synthesis, and biological evaluation of novel 4H-chromen-4-one derivatives as antituberculosis agents against multidrug-resistant tuberculosis. Eur J Med Chem. 2020 Mar 1;189:112075. DOI:10.1016/j.ejmech.2020.112075
2411741-01-8 suppliers list
Company Name: TargetMol Chemicals Inc.  
Telephone: 15002134094
Website: https://www.targetmol.cn/
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