| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [form ]
Solid | [color ]
Off-white to light yellow | [InChIKey]
PGNLXEBQMQHFNK-XGTFWIOGNA-N | [SMILES]
FC1C=CC(C)=C2NC(C(=O)N[C@@H]3CCC[C@H](N4CCN(C(=O)C)CC4)C3)=CC=12 |&1:12,16,r| |
| Hazard Information | Back Directory | [Uses]
EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 (IC50=18 nM in SETD2 biochemical assay; IC50=34 nM in cellular assay). EZM0414 can be used for the research of relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma[1]. | [in vivo]
EZM0414 (15 and 30 mg/kg, p.o., BID, daily, ) inhibits tumor growth in NOD SCID mouse xenograft model implanted with human KMS-11 cells, and is well-tolerated[3].
EZM0414 (50 mg/kg, p.o.) shows almost 100% oral bioavailability in rats and mice, t1/2 of 1.8 h (mice)and 3.8 h (rats)[3].
| [IC 50]
SETD2/KMT3A | [storage]
Store at -20°C | [References]
[1] Jennifer Totman, et al. Pharmacologic Inhibition of the Histone Methyltransferase SETD2 with EZM0414 As a Novel Therapeutic Strategy in Relapsed or Refractory Multiple Myeloma and Diffuse Large B-cell Lymphoma.
[2] Jennifer Totman, et al. Pharmacologic Inhibition of the Histone Methyltransferase SETD2 with EZM0414 As a Novel Therapeutic Strategy in Relapsed or Refractory Multiple Myeloma and Diffuse Large B-Cell Lymphoma. Blood. Volume 138, Supplement 1, 23 November 2021, Page 1142.
[3] Alford JS, et al. Conformational-Design-Driven Discovery of EZM0414: A Selective, Potent SETD2 Inhibitor for Clinical Studies. ACS Med Chem Lett. 2022 Jun 7;13(7):1137-1143. DOI:10.1021/acsmedchemlett.2c00167 |
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| Company Name: |
ABBIOCHEM Gold
|
| Tel: |
021-18964309092 18964309092 |
| Website: |
www.abbiochemical.com |
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