| Identification | Back Directory | [Name]
(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycine | [CAS]
2412056-27-8 | [Synonyms]
Thalidomide-5-NH2-CH2-COOH
(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)glycine | [Molecular Formula]
C15H13N3O6 | [MOL File]
2412056-27-8.mol | [Molecular Weight]
331.28 |
| Chemical Properties | Back Directory | [solubility ]
DMSO : 33.33 mg/mL (100.61 mM; Need ultrasonic) | [form ]
Solid | [color ]
Light yellow to green yellow | [InChI]
InChI=1S/C15H13N3O6/c19-11-4-3-10(13(22)17-11)18-14(23)8-2-1-7(16-6-12(20)21)5-9(8)15(18)24/h1-2,5,10,16H,3-4,6H2,(H,20,21)(H,17,19,22) | [InChIKey]
ZATMCTCUKSYXHM-UHFFFAOYSA-N | [SMILES]
O=C1C2=CC(NCC(=O)O)=CC=C2C(=O)N1C1CCC(=O)NC1=O |
| Hazard Information | Back Directory | [Biological Activity]
Thalidomide-5-NH2-CH2-COOH (compound 114) is a potent and selective inhibitor of tropomyosin receptor kinase (trk). Thalidomide-5-NH2-CH2-COOH is a ligand of E3 ligase. Thalidomide-5-NH2-CH2-COOH has the potential for researching one or more diseases (extracted from patent WO2021170109A1)[1]. | [References]
[1]. Jing Liu, et al. Tropomyosin receptor kinase (trk) degradation compounds and methods of use. Patent WO2021170109A1. |
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