| Identification | Back Directory | [Name]
2H-1-Benzopyran-2-one, 7-[2-(methoxyimino)-2-(2-thiazolyl)ethoxy]-4-methyl- | [CAS]
2412592-33-5 | [Synonyms]
Antimicrobial agent-2
7-(2-(Methoxyimino)-2-(thiazol-2-yl)ethoxy)-4-methyl-2H-chromen-2-one
2H-1-Benzopyran-2-one, 7-[2-(methoxyimino)-2-(2-thiazolyl)ethoxy]-4-methyl- | [Molecular Formula]
C16H14N2O4S | [MOL File]
2412592-33-5.mol | [Molecular Weight]
330.36 |
| Chemical Properties | Back Directory | [Boiling point ]
518.2±60.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
1.27±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Antimicrobial agent-2 (compound V-a) is a broad-spectrum antimicrobial agent, possessing inhibitory activity against various Gram-positive and -negative bacteria. Antimicrobial agent-2 has excellent inhibitory effect on Methicillin-resistant Staphylococcus aureus (MRSA) with a MIC of 1 μg/mL. Antimicrobial agent-2 can effectively damage the membrane and lead to the leakage of protein, also can induce the generation of ROS. Antimicrobial agent-2 exhibits low toxicity, no obvious resistance and good bioavailability[1]. | [References]
[1] Yang XC, et al. Coumarin thiazoles as unique structural skeleton of potential antimicrobial agents. Bioorg Chem. 2022;124:105855. DOI:10.1016/j.bioorg.2022.105855 |
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