| Identification | Back Directory | [Name]
1-Propanone, 3,3,3-trifluoro-2-methoxy-1-[(7S)-7-(2-methoxyphenyl)-3,9-diazaspiro[5.5]undec-3-yl]-2-phenyl-, (2R)- | [CAS]
2413068-25-2 | [Synonyms]
1-Propanone, 3,3,3-trifluoro-2-methoxy-1-[(7S)-7-(2-methoxyphenyl)-3,9-diazaspiro[5.5]undec-3-yl]-2-phenyl-, (2R)- | [Molecular Formula]
C26H31F3N2O3 | [MOL File]
2413068-25-2.mol | [Molecular Weight]
476.53 |
| Chemical Properties | Back Directory | [Boiling point ]
575.1±50.0 °C(predicted) | [density ]
1.25±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
10.49±0.40(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
(7S)-BAY-593 is the S-enantiomer of BAY-593 (HY-161573). BAY-593 is an orally active GGTase-I inhibitor. BAY-593 can block YAP1/TAZ signaling in animals and has antitumor activity[1]. | [IC 50]
YAP/TAZ-TEAD; GGTase I | [References]
[1] Graham K, et al. Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling. Cell Chem Biol. 2024 Mar 19:S2451-9456(24)00087-4. DOI:10.1016/j.chembiol.2024.02.013 |
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