| Identification | Back Directory | [Name]
2(3H)-Thiazolone, 4-(4-methylphenyl)-3-phenyl-, 2-[1-methyl-2-[[4-[2-(methylthio)-1H-benzimidazol-1-yl]-2-thiazolyl]amino]ethylidene]hydrazone | [CAS]
2413565-18-9 | [Synonyms]
COX-2-IN-28
2(3H)-Thiazolone, 4-(4-methylphenyl)-3-phenyl-, 2-[1-methyl-2-[[4-[2-(methylthio)-1H-benzimidazol-1-yl]-2-thiazolyl]amino]ethylidene]hydrazone | [Molecular Formula]
C30H27N7S3 | [MOL File]
2413565-18-9.mol | [Molecular Weight]
581.78 |
| Hazard Information | Back Directory | [Uses]
COX-2-IN-28 is a potent and selective COX-2 inhibitor with IC50 values of 0.054, 2.14, 13.21 μM for COX-2, 15-LOX, COX-1,respectively[1]. | [IC 50]
COX-1: 13.21 μM (IC50); COX-2: 0.054 μM (IC50); 15-LOX: 2.14 μM (IC50) | [References]
[1] Maghraby MT, et al. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes. Bioorg Med Chem. 2020 Apr 1;28(7):115403. DOI:10.1016/j.bmc.2020.115403 |
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