ChemicalBook--->CAS DataBase List--->2413603-10-6

2413603-10-6

Request For Quotation
2413603-10-6 Structure

2413603-10-6 Structure
IdentificationBack Directory
[Name]

Benzamide, 4-(9-acridinylamino)-N-hydroxy-
[CAS]

2413603-10-6
[Synonyms]

HDAC6-IN-6
Benzamide, 4-(9-acridinylamino)-N-hydroxy-
[Molecular Formula]

C20H15N3O2
[MOL File]

2413603-10-6.mol
[Molecular Weight]

329.35
Chemical PropertiesBack Directory
[density ]

1.382±0.06 g/cm3(Predicted)
[pka]

9.06±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

HDAC6-IN-6 (compound 6a) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-6 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-6 can enhance neurite outgrowth without significant neurotoxicity[1].
[IC 50]

HDAC6: 0.025 ± 0. μM (IC50); HDAC1: 0.34 ± 0.0 μM (IC50); HDAC: 0.55 ± 0.0 μM (IC50); HDAC9: 0.57 ± 0.0 μM (IC50); HDAC7: 0.65 ± 0.0 μM (IC50); HDAC5: 0.85 ± 0.0 μM (IC50); HDAC3: 1.22 ± 0.0 μM (IC50); HDAC2: 1.57 ± 0.0 μM (IC50); HDAC4: 2.24 ± 0.0 μM (IC50)
[References]

[1] Tseng HJ, et al. Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease. Eur J Med Chem. 2020 Apr 15;192:112193. DOI:10.1016/j.ejmech.2020.112193
2413603-10-6 suppliers list
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Telephone: 13816613772
Website: https://www.chemicalbook.com/ShowSupplierProductsList16976/0_EN.htm
Company Name: Jinan Jiuli Biotechnology Co. , Ltd.  
Telephone: 15865264761
Website: www.chemicalbook.com/ShowSupplierProductsList89365/0_EN.htm
Company Name: TargetMol Chemicals Inc.  
Telephone: 15002134094
Website: https://www.targetmol.cn/
Tags:2413603-10-6 Related Product Information
2568868-35-7 1616493-44-7 107761-42-2 1821-12-1 128517-07-7