| Identification | Back Directory | [Name]
1(3H)-Isobenzofuranone, 5,6-dimethoxy-3-[6-[methyl(phenylmethyl)amino]hexylidene]-, (3Z)- | [CAS]
2413656-04-7 | [Synonyms]
AChE-IN-21
1(3H)-Isobenzofuranone, 5,6-dimethoxy-3-[6-[methyl(phenylmethyl)amino]hexylidene]-, (3Z)- | [Molecular Formula]
C24H29NO4 | [MOL File]
2413656-04-7.mol | [Molecular Weight]
395.49 |
| Hazard Information | Back Directory | [Uses]
AChE-IN-21 (Compound I-8) is a potent, selective and orally active AChE inhibitor with an IC50 of 2.66 nM. AChE-IN-21 displays excellent BBB permeability in vitro[1]. | [in vivo]
AChE-IN-21 (Compound I-8) (0-25 mg/kg; i.g.; once a day for 7 consecutive days) significantly reverses scopolamine-induced memory deficit in mice[1]. | Animal Model: | Kunming mice at body weight of 18–22 g (male and female in half)[1] | | Dosage: | 1.0, 5.0 and 25.0 mg/kg | | Administration: | Intragastric administration, once a day for 7 consecutive days | | Result: | Obviously blocked scopolamine (2 mg/kg, i.p.)-induced memory deficit. |
| [IC 50]
EeAChE: 2.66 nM (IC50); RatBuChE: 19.10 μM (IC50) | [References]
[1] Luo L, et al. Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease. Bioorg Med Chem. 2020 Apr 15;28(8):115400. DOI:10.1016/j.bmc.2020.115400 |
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