| Identification | Back Directory | [Name]
Ethanone, 1-[2-[[3-(4-fluorophenyl)-5-methyl-4-isoxazolyl]methoxy]-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]-2-(methylsulfonyl)- | [CAS]
2413850-54-9 | [Synonyms]
GABAA receptor modulator-2
Ethanone, 1-[2-[[3-(4-fluorophenyl)-5-methyl-4-isoxazolyl]methoxy]-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]-2-(methylsulfonyl)- | [Molecular Formula]
C22H22FN3O5S | [MOL File]
2413850-54-9.mol | [Molecular Weight]
459.49 |
| Hazard Information | Back Directory | [Uses]
GABAA receptor modulator-2 (Compound 20) is selective, orally active α5-GABAAR negative allosteric modulator (NAM) with a Ki of 4.1 nM. GABAA receptor modulator-2 shows high-metabolic stability and good CNS safety[1]. | [in vivo]
GABAA receptor modulator-2 (Compound 20) (0-10 mg/kg) produces a dose-dependent reversal of the PCP-induced cognitive deficit in the rat subPCP NOR test[1]. | [References]
[1] Szabó G, et al. Multiparameter Optimization of Naphthyridine Derivatives as Selective α5-GABAA Receptor Negative Allosteric Modulators. J Med Chem. 2022 Jun 9;65(11):7876-7895. DOI:10.1021/acs.jmedchem.2c00414 |
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