| Identification | Back Directory | [Name]
Benzamide, N-[3-[(6-chloro-1,2,3,4-tetrahydro-9-acridinyl)amino]propyl]-4-[(1E)-3-(hydroxyamino)-3-oxo-1-propen-1-yl]- | [CAS]
2414053-06-6 | [Synonyms]
AChE/HDAC-IN-1
Benzamide, N-[3-[(6-chloro-1,2,3,4-tetrahydro-9-acridinyl)amino]propyl]-4-[(1E)-3-(hydroxyamino)-3-oxo-1-propen-1-yl]- | [Molecular Formula]
C26H27ClN4O3 | [MOL File]
2414053-06-6.mol | [Molecular Weight]
478.97 |
| Hazard Information | Back Directory | [Uses]
COX-2-IN-23 (compound A10) is a potent both AChE and HDAC inhibitor with IC50 values of 0.12 and 0.23 nM. COX-2-IN-23 exhibits antioxidant activity and metal chelating properties. COX-2-IN-23 can be used in alzheimer's disease research[1]. | [IC 50]
HDAC: 0.23 nM (IC50) | [References]
[1] Xu A, et al. Tacrine-hydroxamate derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation. Bioorg Chem. 2020 May;98:103721. DOI:10.1016/j.bioorg.2020.103721 |
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