2414373-42-3

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2414373-42-3 Structure

Identification	Back Directory
[Name] 4-[5-(4-Pyridylmethylamino)pyrazolo[1,5-a]pyrimidin-3-yl]benzamide
[CAS] 2414373-42-3
[Synonyms] DUN73423 RETV804M inhibitor 4-[5-(4-Pyridylmethylamino)pyrazolo[1,5-a]pyrimidin-3-yl]benzamide
[Molecular Formula] C19H16N6O
[MOL File] 2414373-42-3.mol
[Molecular Weight] 344.37

Chemical Properties	Back Directory
[density ] 1.38±0.1 g/cm3(Predicted)
[form ] Solid
[pka] 15.59±0.50(Predicted)
[color ] Off-white to light yellow

Hazard Information	Back Directory
[Description] DUN73423 is a RET/KDR-Selective Inhibitor of RETV804M Kinase with IC50 = 7 nM. DUN73423 was listed in ACS Med Chem Lett . 2020 Feb 28;11(4):497-505 (compound 5). This product has no formal name at the moment.
[Uses] RET-IN-21 is an inhibitor of receptor tyrosine kinase (RET), with the IC50 of 4.4 μM, that has antitumor activity[1].
[References] [1] Rebecca Newton, et al. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RETV804M Kinase. ACS Med. Chem. Lett. 2020, 11, 4, 497–505

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