| Identification | Back Directory | [Name]
Acetamide, N-[3-[[5-chloro-2-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]- | [CAS]
2414373-55-8 | [Synonyms]
CDK6/9-IN-1
Acetamide, N-[3-[[5-chloro-2-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]- | [Molecular Formula]
C22H25ClN8O | [MOL File]
2414373-55-8.mol | [Molecular Weight]
452.94 |
| Hazard Information | Back Directory | [Uses]
CDK6/9-IN-1 (compound 66) is an orally active active and dual CDK 6 and CDK 9 inhibitor, with IC50 values of 40.5 nM and 39.5 nM for CDK6 anmd CDK9, respectively[1]. | [in vivo]
CDK6/9-IN-1 (compound 66) significantly inhibits tumor growth in an xenograft mouse model with no obvious toxicity, indicating the promising therapeutic potential of CDK6/9 dual inhibitors for cancer treatment[1]. | [IC 50]
CDK6: 40.5 nM (IC50); CDK9: 39.5 nM (IC50) | [References]
[1] Yang Wang, et al. Discovery and SARs of 5-Chloro- N4-phenyl- N2-(pyridin-2-yl)pyrimidine-2,4-diamine Derivatives as Oral Available and Dual CDK 6 and 9 Inhibitors With Potent Antitumor Activity. J Med Chem. 2020 Mar 26;63(6):3327-3347. DOI:10.1021/acs.jmedchem.9b02121 |
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