| Identification | Back Directory | [Name]
Cyclopropaneacetic acid, α-hydroxy-, phenylmethyl ester, (αS)- | [CAS]
2414393-48-7 | [Synonyms]
Cyclopropaneacetic acid, α-hydroxy-, phenylmethyl ester, (αS)- | [Molecular Formula]
C12H14O3 | [MOL File]
2414393-48-7.mol | [Molecular Weight]
206.24 |
| Chemical Properties | Back Directory | [Boiling point ]
326.2±17.0 °C(Predicted) | [density ]
1.234±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
12.90±0.20(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
(S)-Benzyl 2-cyclopropyl-2-hydroxyacetate is an intermediate reactant in the synthesis of Camptothecin (HY-16560). Camptothecin is an inhibitor of the DNA topoisomerase Topo I, withIC50=679 nM[1][2]. | [References]
[1] Li Zhen, et al. Camptothecin derivative, and pharmaceutical composition and use thereof. World Intellectual Property Organization, WO2023020605 A1. 2023-02-23.
[2] Huang Q, et al. Evolution in medicinal chemistry of E-ring-modified Camptothecin analogs as anticancer agents. Eur J Med Chem. 2013;63:746-757. DOI:10.1016/j.ejmech.2013.01.058 |
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